| Proud
flesh (excessive tissue granulation) and hair discoloration at regrowth
are induced by several factors (e.g. the use of mutagenic or cytogenotoxic
substances on wounds).
Derma GeL® has been tested in accordance with the OECD
Guideline 471 - Genetic Toxicology - Reverse Mutation Assay. The
four strains used for this assay are : TA 98, TA 100, TA
1535 an TA 1537 – originating from the Laboratory of Professor
B. AMES, California University, Biochem. Department, US.A 20.
It
has been observed through this study that - with or without metabolic
activation - when compared versus negative controls (DMSO and
Tph), Derma GeL® is totally devoid of cytogenotoxic
/ mutagenic effect.
In conclusion, the absence of mutation, alteration or denaturation
of cells ensures that skin traumas are re-covered by cells genetically
and completely identical to the cells that were initially available
= NO proud flesh
and NO hair discoloration at regrowth.
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